This is the analysis of the relationship between white matter microstructure and hormones across pregnancy in one single subject.
One subject and a total of 25 scans from July 2019 to May 2021. Scans range from baseline to IVF to post pregnancy. The number of scans in the analyses varies by hormone analysis and time.
18 scans were preprocessed successfully. 7 scans removed due to issues with the DWI.
QA was positively correlated with estrogen levels across numerous tracts including corpus callosum and cingulum. DSI found tracts in the cerebellum with AD, RD, and MD were negatively associated with estrogen levels. Suggesting that increased levels of estrogen are associated with better white matter micro structure. When analyzing pregnancy only scans, DSI only found significant results in the QA analysis. QA was positively associated with estrogen levels.
| Tract Name | number of tracts | mean length(mm) | diameter(mm) | volume(mm^3) |
|---|---|---|---|---|
| Corticospinal_Tract_L | 639 | 61.6495 | 10.9617 | 5818 |
| Corpus_Callosum_Forceps_Major | 424 | 59.2877 | 9.10471 | 3860 |
| Inferior_Longitudinal_Fasciculus_L | 288 | 62.1736 | 8.17073 | 3260 |
| Middle_Cerebellar_Peduncle | 259 | 63.5907 | 10.5273 | 5535 |
| Corpus_Callosum_Tapetum | 243 | 54.5021 | 10.8595 | 5048 |
| Medial_Lemniscus_L | 188 | 55.734 | 7.46909 | 2442 |
| Corpus_Callosum_Body | 182 | 58.4286 | 9.41874 | 4071 |
| Inferior_Fronto_Occipital_Fasciculus_R | 168 | 56.5 | 7.31889 | 2377 |
| Inferior_Longitudinal_Fasciculus_R | 126 | 59.6032 | 7.05199 | 2328 |
| Inferior_Fronto_Occipital_Fasciculus_L | 115 | 55.7217 | 5.85253 | 1499 |
| Dentatorubrothalamic_Tract_L | 98 | 59.0816 | 7.58976 | 2673 |
| Corticostriatal_Tract_Superior_L | 92 | 53.5435 | 6.06523 | 1547 |
| Cingulum_Frontal_Parietal_L | 84 | 58.3095 | 4.58324 | 962 |
| Corticostriatal_Tract_Posterior_L | 82 | 60.3659 | 5.98274 | 1697 |
| Cingulum_Frontal_Parietal_R | 80 | 55.85 | 4.30251 | 812 |
| Thalamic_Radiation_Posterior_L | 36 | 55.3333 | 4.9666 | 1072 |
| Corticopontine_Tract_Parietal_L | 34 | 58.7647 | 5.12869 | 1214 |
No significant Findings
Positive Correlations between QA and Estrogen across pregnancy stages
Positive Correlations between QA and Estrogen across pregnancy stages
Positive Correlations between QA and Estrogen across pregnancy stages
| Tract Name | number of tracts | mean length(mm) | diameter(mm) | volume(mm^3) |
|---|---|---|---|---|
| Middle_Cerebellar_Peduncle | 1420 | 63.393 | 18.2287 | 16544 |
| Corticospinal_Tract_L | 1293 | 61.1524 | 14.0396 | 9467 |
| Corpus_Callosum_Body | 683 | 59.8184 | 14.5339 | 9924 |
| Dentatorubrothalamic_Tract_L | 380 | 65.8947 | 13.3155 | 9176 |
| Medial_Lemniscus_L | 369 | 56.0217 | 10.6003 | 4944 |
| Corticostriatal_Tract_Posterior_L | 153 | 59.1111 | 7.06606 | 2318 |
| Corpus_Callosum_Forceps_Major | 145 | 56.7724 | 7.89319 | 2778 |
| Corticostriatal_Tract_Superior_L | 124 | 54.8387 | 8.87441 | 3392 |
| Cingulum_Frontal_Parietal_L | 89 | 58.0899 | 4.85636 | 1076 |
| Inferior_Longitudinal_Fasciculus_L | 80 | 60.35 | 6.18806 | 1815 |
| Medial_Lemniscus_R | 80 | 57.475 | 6.86919 | 2130 |
| Corpus_Callosum_Tapetum | 75 | 55.76 | 7.83736 | 2690 |
| Thalamic_Radiation_Posterior_L | 72 | 54.0278 | 6.93194 | 2039 |
| Dentatorubrothalamic_Tract_R | 67 | 103.075 | 7.12265 | 4107 |
| Extreme_Capsule_R | 61 | 57.5082 | 5.19721 | 1220 |
| Arcuate_Fasciculus_L | 60 | 54.4333 | 5.83985 | 1458 |
| Superior_Longitudinal_Fasciculus1_R | 59 | 57.2881 | 5.31908 | 1273 |
No significant Findings
No significant findings
| Tract Name | number of tracts | mean length(mm) | diameter(mm) | volume(mm^3) |
|---|---|---|---|---|
| Cerebellum_L | 98 | 53.4694 | 5.01695 | 1057 |
| Cerebellum_R | 61 | 52.3607 | 4.86667 | 974 |
| Middle_Cerebellar_Peduncle | 16 | 56.125 | 2.74439 | 332 |
Negative Correlations between MD and Estrogen across pregnancy stages
Negative Correlations between MD and Estrogen across pregnancy stages
Negative Correlations between MD and Estrogen across pregnancy stages
No significant findings
| Tract Name | number of tracts | mean length(mm) | diameter(mm) | volume(mm^3) |
|---|---|---|---|---|
| Cerebellum_R | 8 | 51.5 | 2.32156 | 218 |
| Cerebellum_L | 7 | 50.2857 | 2.7744 | 304 |
| Tract Name | number of tracts | mean length(mm) | diameter(mm) | volume(mm^3) |
|---|---|---|---|---|
| Cerebellum_R | 90 | 52.3333 | 5.41676 | 1206 |
| Cerebellum_L | 75 | 53.68 | 4.24297 | 759 |
Negative Correlations between AD and Estrogen across pregnancy stages
No significant findings
| Tract Name | number of tracts | mean length(mm) | diameter(mm) | volume(mm^3) |
|---|---|---|---|---|
| Cerebellum_L | 40 | 52.85 | 4.43382 | 816 |
| Cerebellum_R | 6 | 51.3333 | 1.88332 | 143 |
| Tract Name | number of tracts | mean length(mm) | diameter(mm) | volume(mm^3) |
|---|---|---|---|---|
| Cerebellum_L | 179 | 53.0838 | 6.30618 | 1658 |
| Cerebellum_R | 129 | 52.5271 | 6.49252 | 1739 |
| Middle_Cerebellar_Peduncle | 46 | 54.7826 | 4.28496 | 790 |
Negative Correlations between RD and Estrogen across pregnancy stages
No significant findings
DSI found significant positive and negative correlations between QA and progesterone in various tracts. There were positive and negative correlations between progesterone and AD, RD, and MD but most of the tracts show a positive association. This suggests that higher levels of progesterone may be associated with decreased or altered white matter integrity and increased levels of diffusion. When analyzing pregnancy only, DSI found significant positive correlations with QA only. Interestingly, it appears that tracts in the cerebellum have the opposite relationship with progesterone compared to estrogen. Tracts in the cerebellum show a positive relationship between progesterone and AD, MD and MD. This suggests that higher levels of progesterone in the cerebellum are associated with increased levels of diffusion, a typical signal of weakened or decreased white matter integrity.
| Tract Name | number of tracts | mean length(mm) | diameter(mm) | volume(mm^3) |
|---|---|---|---|---|
| Middle_Cerebellar_Peduncle | 977 | 64.52 | 15.6524 | 12415 |
| Corticospinal_Tract_L | 682 | 60.9413 | 11.9018 | 6780 |
| Corpus_Callosum_Forceps_Major | 612 | 59.8987 | 10.5649 | 5251 |
| Corpus_Callosum_Body | 472 | 58.4661 | 12.5027 | 7178 |
| Corpus_Callosum_Tapetum | 354 | 55.3559 | 11.9003 | 6157 |
| Inferior_Fronto_Occipital_Fasciculus_R | 352 | 59.733 | 8.83139 | 3659 |
| Inferior_Longitudinal_Fasciculus_R | 266 | 61.2932 | 8.70873 | 3651 |
| Medial_Lemniscus_L | 236 | 55.5847 | 8.50652 | 3159 |
| Dentatorubrothalamic_Tract_L | 157 | 64.8408 | 9.4502 | 4548 |
| Cingulum_Frontal_Parietal_R | 146 | 56.6027 | 5.70717 | 1448 |
| Cingulum_Frontal_Parietal_L | 135 | 60.0889 | 5.78977 | 1582 |
| Arcuate_Fasciculus_L | 120 | 55.9333 | 6.5644 | 1893 |
| Corticostriatal_Tract_Posterior_L | 92 | 63.3913 | 6.47753 | 2089 |
| Corticostriatal_Tract_Superior_L | 91 | 54.044 | 6.85056 | 1992 |
| Arcuate_Fasciculus_R | 81 | 56.6914 | 6.80685 | 2063 |
| Thalamic_Radiation_Posterior_L | 76 | 55.6842 | 6.22917 | 1697 |
| Medial_Lemniscus_R | 72 | 57.3611 | 5.9464 | 1593 |
| Extreme_Capsule_R | 56 | 57.0357 | 4.56131 | 932 |
| Tract Name | number of tracts | mean length(mm) | diameter(mm) | volume(mm^3) |
|---|---|---|---|---|
| Inferior_Longitudinal_Fasciculus_R | 152 | 61.9605 | 6.64995 | 2152 |
| Inferior_Fronto_Occipital_Fasciculus_R | 113 | 61.0088 | 7.03584 | 2372 |
| Inferior_Fronto_Occipital_Fasciculus_L | 63 | 56.6667 | 5.56639 | 1379 |
| Cerebellum_L | 57 | 54.1053 | 5.27851 | 1184 |
| Corpus_Callosum_Forceps_Minor | 39 | 56.3077 | 4.80725 | 1022 |
| Corpus_Callosum_Forceps_Major | 31 | 57.0323 | 2.98457 | 399 |
| Corpus_Callosum_Body | 27 | 55.9259 | 4.52154 | 898 |
| Optic_Radiation_L | 24 | 57 | 3.83672 | 659 |
| Anterior_Commissure | 21 | 61.8095 | 4.02638 | 787 |
| Middle_Cerebellar_Peduncle | 18 | 60.7778 | 3.09415 | 457 |
| Cerebellum_R | 11 | 51.8182 | 2.06771 | 174 |
| Vermis | 10 | 51.2 | 2.25235 | 204 |
| Corticostriatal_Tract_Posterior_L | 8 | 60.5 | 2.67889 | 341 |
Positive Correlations between QA and Progesterone across pregnancy stages
Negative Correlations between QA and Progesterone across pregnancy stages
Positive and Negative Correlations between QA and Progesterone across pregnancy stages
| Tract Name | number of tracts | mean length(mm) | diameter(mm) | volume(mm^3) |
|---|---|---|---|---|
| Middle_Cerebellar_Peduncle | 1143 | 63.0534 | 16.8659 | 14087 |
| Corticospinal_Tract_L | 480 | 59.4708 | 11.012 | 5664 |
| Medial_Lemniscus_L | 204 | 56.0196 | 8.01015 | 2823 |
| Corpus_Callosum_Body | 173 | 58.4624 | 9.63098 | 4259 |
| Dentatorubrothalamic_Tract_L | 150 | 68.2533 | 9.47055 | 4808 |
| Corticostriatal_Tract_Superior_L | 68 | 55.1765 | 6.18544 | 1658 |
| Medial_Lemniscus_R | 58 | 55.931 | 5.89201 | 1525 |
| Corticopontine_Tract_Parietal_L | 42 | 63.0476 | 5.56587 | 1534 |
| Thalamic_Radiation_Posterior_L | 39 | 55.8974 | 4.85779 | 1036 |
| Dentatorubrothalamic_Tract_R | 32 | 106.75 | 5.46498 | 2504 |
| Corticostriatal_Tract_Posterior_L | 30 | 61.2 | 4.79469 | 1105 |
| Superior_Longitudinal_Fasciculus1_R | 29 | 54.9655 | 3.49725 | 528 |
| Inferior_Cerebellar_Peduncle_R | 28 | 83.5 | 4.77615 | 1496 |
No significant Findings
| Tract Name | number of tracts | mean length(mm) | diameter(mm) | volume(mm^3) |
|---|---|---|---|---|
| Cerebellum_R | 358 | 54.1955 | 11.1692 | 5310 |
| Cerebellum_L | 214 | 54.1776 | 7.25229 | 2238 |
| Corpus_Callosum_Forceps_Major | 106 | 56.3396 | 6.36381 | 1792 |
| Vermis | 78 | 55.7692 | 5.39738 | 1276 |
| Fornix_R | 39 | 55.6923 | 3.66957 | 589 |
| Corpus_Callosum_Tapetum | 34 | 59.3529 | 4.43284 | 916 |
| Middle_Cerebellar_Peduncle | 14 | 53.5714 | 3.33868 | 469 |
| Tract Name | number of tracts | mean length(mm) | diameter(mm) | volume(mm^3) |
|---|---|---|---|---|
| Cerebellum_R | 68 | 51.4118 | 4.61501 | 860 |
| Cerebellum_L | 50 | 53.6 | 3.81595 | 613 |
Positive Correlations between MD and Progesterone across pregnancy stages
Positive Correlations between MD and Progesterone across pregnancy stages
Negative Correlations between MD and Progesterone across pregnancy stages
Negative Correlations between MD and Progesterone across pregnancy stages
Positive and Negative Correlations between MD and Progesterone across pregnancy stages
Positive and Negative Correlations between MD and Progesterone across pregnancy stages
No significant Findings
| Tract Name | number of tracts | mean length(mm) | diameter(mm) | volume(mm^3) |
|---|---|---|---|---|
| Cerebellum_R | 244 | 53.8361 | 9.61012 | 3905 |
| Cerebellum_L | 208 | 54.5288 | 6.49563 | 1807 |
| Middle_Cerebellar_Peduncle | 60 | 56.7 | 4.59194 | 939 |
| Corpus_Callosum_Forceps_Major | 20 | 53.4 | 4.06198 | 692 |
| Vermis | 17 | 53.0588 | 2.88563 | 347 |
| Corpus_Callosum_Forceps_Minor | 13 | 52.4615 | 2.92699 | 353 |
| Tract Name | number of tracts | mean length(mm) | diameter(mm) | volume(mm^3) |
|---|---|---|---|---|
| Cerebellum_R | 65 | 51.1692 | 4.0525 | 660 |
| Cerebellum_L | 20 | 54.5 | 2.22023 | 211 |
Positive Correlations between AD and Progesterone across pregnancy stages
Positive Correlations between AD and Progesterone across pregnancy stages
Negative Correlations between AD and Progesterone across pregnancy stages
Negative Correlations between AD and Progesterone across pregnancy stages
Positive and Negative Correlations between AD and Progesterone across pregnancy stages
No significant Findings
| Tract Name | number of tracts | mean length(mm) | diameter(mm) | volume(mm^3) |
|---|---|---|---|---|
| Cerebellum_R | 572 | 54.5594 | 12.4219 | 6612 |
| Cerebellum_L | 312 | 54.2756 | 8.68446 | 3215 |
| Vermis | 120 | 55.4 | 6.81696 | 2022 |
| Corpus_Callosum_Forceps_Major | 76 | 55.7105 | 5.52366 | 1335 |
| Corpus_Callosum_Tapetum | 34 | 55.8824 | 4.14755 | 755 |
| Middle_Cerebellar_Peduncle | 25 | 54.4 | 4.39689 | 826 |
| Fornix_R | 20 | 54 | 3.48467 | 515 |
| Anterior_Commissure | 15 | 54.4 | 3.02513 | 391 |
| Tract Name | number of tracts | mean length(mm) | diameter(mm) | volume(mm^3) |
|---|---|---|---|---|
| Middle_Cerebellar_Peduncle | 162 | 55.2346 | 7.84375 | 2669 |
| Cerebellum_L | 125 | 53.04 | 5.12462 | 1094 |
| Cerebellum_R | 124 | 52.5484 | 5.98631 | 1479 |
Positive Correlations between RD and Progesterone across pregnancy stages
Positive Correlations between RD and Progesterone across pregnancy stages
Negative Correlations between RD and Progesterone across pregnancy stages
Negative Correlations between RD and Progesterone across pregnancy stages
Positive and Negative Correlations between RD and Progesterone across pregnancy stages
Positive and Negative Correlations between RD and Progesterone across pregnancy stages
No significant Findings